Objective: Objective: JUVENILE dermatomyoistis (JDMS) involves children rarely. Our purpose of this study is to detect clinical and laboratory aspects of this disorder and its treatment in Khorasan Province. Material & Methods: A 10-years retrospective study performed on medical records of all patients with JDMS in a medical center in Mashhad. Data was analyzed with statistical measures including SPSS and Excel. Findings: 18 patients had DJMS during 10 years. There was a female to male predominance (1.25/1). The mean age of patients was 12.1 years. Muscular weakness was the most common presenting symptom. Skin involvement including heliotrope rash and Gottron papules were detected in most patients. Elevated muscular enzymes were an important finding in many cases. EMG, and muscle biopsy in those cases performed, showed abnormal results. Seventeen (94.5%) of patients responded to oral prednisolon therapy.Conclusion: According to clinical manifestations and laboratory findings, in particular muscular enzyme assays, a timely diagnosis and treatment with oral prednisolon can improve the disease dramatically and reduce morbidity and mortality rates as well.

Introduction:An 8-year-old Iranian girl was referred because she had progressive muscle weakness predominantly in lower limbs since about 2 years ago. She was not able to stand from a sitting position without help and had difficulty climbing stairs. She walked slowly and could not run like before. She had no complaint of dysphagia or dysphonia.

JUVENILE DERMATOMYOSITIS (JDM) is a rare idiopathic inflammatory disease, which usually presents with skin rashes along with muscle weakness. We report a case of JDM in a 10-year-old girl with no skin manifestations presenting with progressive muscle weakness and fatigue. Further laboratory investigations, along with a muscle biopsy, confirmed the diagnosis of adermatopathic JDM. The patient was treated with intravenous immunoglobulin, corticosteroids, methotrexate, hydroxychloroquine, pamidronate, and rituximab. Following treatment, patients’ symptoms subsided, and she gained normal muscular strength over a year.

JUVENILE clinically amyopathic DERMATOMYOSITIS (JUVENILE CADM) is a rare rheumatologic disease in children defined as the presence of the hallmark cutaneous features of DERMATOMYOSITIS in absence of muscle involvement. In this article, we report an Iranian 14. 5-year-old girl presented to Rheumatology Clinic of Mofid Children’ s Hospital, Tehran, Iran in Jan 2016 with cutaneous complaints diagnosed with JUVENILE CADM. Finally, we provide a literature review of previous studies on JUVENILE CADM.

JUVENILE DERMATOMYOSITIS (JDM) is a rare autoimmune disease characterized by inflammation of the muscle, connective tissue and skin. Although localized edema is seen in JUVENILE DERMATOMYOSITIS, generalized edema has been reported rarely. In this article, we report an 11-year-old girl with JUVENILE DERMATOMYOSITIS presenting with generalized edema and classic sign and symptoms of JUVENILE DERMATOMYOSITIS. In differential diagnosis of generalized edema, JDM should always be kept in mind. Early diagnosis and treatment of those cases by corticosteroids are important to decrease morbidity.

Provisional hypomyopathic JUVENILE DERMATOMYOSITIS is a subgroub of clinically amyopathic JUVENILE DERMATOMYOSITIS provisional. The diagnostic criteria include: classic DERMATOMYOSITIS skin lesions - which have to be confirmed by biopsy - , no , involvementof proximalmuscles,subclinical involvement of these muscles and normal level of muscle enzymes. These criteria should be present for a minimum of 6 months andmaximum of 24 monthHere a l3-year-old boy is presented who developed non Hodgkin lymphoma 15months after the diagnosis of his DERMATOMYOSITIS.

DERMATOMYOSITIS (DM) is a rare idiopathic inflammatory myopathy with characteristic skin lesions. Case series have shown an association between DERMATOMYOSITIS and malignancy. Malignancy has been found in 15-25% of the adult patients with DERMATOMYOSITIS.A 50-year-old new case of breast cancer was admitted with muscle weakness and inability to walk. Physical examination revealed fever, periorbital edema, a heliotrope rash on the upper eyelids, large right-sided breast mass and erythematous plaques on the upper chest, abdomen and legs. During hospitalization, she developed a nasal speech, dysphasia, and nasal regurgitation of food and water.A clinical diagnosis of DERMATOMYOSITIS secondary to breast adenocarcinoma was made according to the skin lesions, muscle weakness, elevated ESR, and increased CPK and LDH levels. Wide spectrum antibiotics and Dexamethasone were administered but fever persisted. Although chemotherapy was recommended, she developed respiratory failure and aspiration pneumonia and died.DERMATOMYOSITIS is one of the paraneoplastic syndromes which are associated with breast cancer. Although treatment of DERMATOMYOSITIS generally includes corticosteroids with or without immunosuppressants, cancerdirected specific therapy including surgery and/or chemotherapy would be more effective. DERMATOMYOSITIS should be considered in breast cancer patients with skin lesions and muscle weakness and cancer-specific therapy should be started as soon as possible.